The negative bone effects of the disease and of chronic corticosteroid treatment in premenopausal women affected by rheumatoid arthritis
Osteoporosis is a well-known extra-articular complication in rheumatoid arthritis (RA).The chronic corticosteroid treatment, the functional impairment associated with RA and the disease itself appear to be the most relevant determinants.Most of the previous studies involved postmenopausal women, in whom the estrogenic deficiency might amplify the n